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Tera-BLAST™
The ubiquitous nucleic and protein homology search tool, just faster
BLAST is a critical algorithm with broad applications from
genome analysis to SNP mapping and proteomics research.
With its heuristic design, it delivers results faster
than dynamic programming methods such as Smith-Waterman. And yet the tremendous volumes of data generated by next-generation sequencing platforms can lead to days or weeks per BLAST search—even on a large
cluster.
Several software implementations of BLAST exist from NCBI, Washington University and others. Tera-BLAST is
a faithful implementation of BLAST software that executes on the TimeLogic FPGA-based NextEngine accelerator. Tera-BLAST derives its name the trillions (tera) of cell comparisons per second that can be accomplished on the TimeLogic solutions.
The Tera-BLAST algorithm suite is included with the CodeQuest workstations and is an available module for the DeCypher Enterprise solutions, where it complements the other sequence comparison modules, including HMM, SmithWaterman, GeneDetective.
Tera-BLAST Advantages:
- Provides the performance of hundreds of modern CPU cores
in a small-footprint solution
- Higher throughput means you can complete better annotations with standard BLAST methods (BLASTN, BLASTX, TBLASTN, TBLASTX, BLASTP)
- Can be deployed in a desktop computer, or installed across a DeCypher cluster of 20 nodes
- "Nearly exact match" parameters
enable anchoring on very small nucleic patterns (using nucleic wordsize
as low as 4)
- Includes Tera-Probe for mismatch-tolerant high-sensitivity oligo searches
- Tera-BLAST delivers fast,
affordable genome-scale analysis to your labor entire institution
Tera-BLAST™ Search Methods
Algorithm |
Query/
Database |
Description |
Applications |
| Tera-BLASTN |
NT/NT |
Fast nucleotide search, find very similar
matches, ungapped search |
- map 454 reads, EST or cDNAs onto a genome
- identify overlaps for assembly workflows
- running genome to genome comparisons
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| Tera-Probe™ |
NT/NT |
Compare oligos (up to 50bp) to genomic DNA with near-Smith-Waterman sensitivity |
- Identify potential microarray probes
- Map short reads to a genome with up to 5 mismatches
- Map SNPs to a genome with high sensitivity
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| Tera-BLASTP |
AA/AA |
Fast AA search, find easy homologous sequences, ungapped search |
- assign tentative functions
- homology modelling when a match to protein with known
3D structure is found
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| Tera-BLASTX |
NT/AA |
Translate query in all 6 frames, search in AA space., ungapped search |
- assign tentative functions to novel cDNAs or EST
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| Tera-TBLASTN |
AA/NT |
Translate target in all 6 frames search resulting AA sequences, ungapped search |
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| Tera-TBLASTX |
NT/NT |
Translate query and target in all 6 frames, search the AA sequences, ungapped
search |
- compare genomes, more sensitive for comparing coding
regions
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Custom Benchmarks
Contact us today for a sample Tera-BLAST benchmark on your data!
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